(DOWNLOAD) "Activity of Wedelia Calendulacea Less. In Post-Menopausal Osteoporosis (Clinical Report)" by Phytomedicine: International Journal of Phytotherapy & Phytopharmacology ~ eBook PDF Kindle ePub Free

May 20, 2021

eBook details

Title: Activity of Wedelia Calendulacea Less. In Post-Menopausal Osteoporosis (Clinical Report)
Author : Phytomedicine: International Journal of Phytotherapy & Phytopharmacology
Release Date : January 01, 2006
Genre: Life Sciences,Books,Science & Nature,
Pages : * pages
Size : 199 KB

Description

Abstract Wedelia calendulacea Less., a perennial herb containing isoflavanoids, is used in liver disorders, uterine hemorrhage and menorrhagia. Osteoporosis in women occurs mainly due to estrogen deficiency following menopause. Studies indicate that isoflavones are estrogenic enough to promote bone formation. Our study was aimed to investigate the antiosteoporotic effect of the ethanol extract of W. calendulacea in the ovariectomized rat model of osteoporosis, at two different dose levels of 500 and 750 mg/kg/body wt. day. The findings, assessed on the basis of biomechanical and biochemical parameters, showed that the ethanol extract of the plant had a definite protective effect. This was further supported by the histopathological studies. Phytochemical investigation revealed the presence of isoflavones and wedelolactone, which are known to act as phytoestrogens and may be responsible for the antiosteoporotic activity.