[Download] "Acute Anti-Inflammatory Activity of Four Saponins Isolated from Ivy: Alpha-Hederin, Hederasaponin-C, Hederacolchiside-E and Hederacolchiside-F in Carrageenan-Induced Rat Paw Edema." by Phytomedicine: International Journal of Phytotherapy & Phytopharmacology # Book PDF Kindle ePub Free
eBook details
- Title: Acute Anti-Inflammatory Activity of Four Saponins Isolated from Ivy: Alpha-Hederin, Hederasaponin-C, Hederacolchiside-E and Hederacolchiside-F in Carrageenan-Induced Rat Paw Edema.
- Author : Phytomedicine: International Journal of Phytotherapy & Phytopharmacology
- Release Date : January 01, 2005
- Genre: Life Sciences,Books,Science & Nature,
- Pages : * pages
- Size : 228 KB
Description
Abstract The anti-inflammatory potential of [alpha]-hederin (monodesmoside) and hederasaponin-C from Hedera helix, and hederacolchisides-E and -F (bidesmosides) from H. colchica was investigated in carrageenan-induced acute paw edema in rats. Saponins and indomethacin were given orally in concentrations of 0.02 and 20 mg/kg body wt. For the first phase of acute inflammation, indomethacin was found as the most potent drug. [alpha]-hederin and hederasaponin-C were found ineffective, while hederacolchisides-E and -F showed slight anti-inflammatory effects on the first phase. For the second phase of acute inflammation, indomethacin and hederacolchiside-F were determined as very potent compounds. [alpha]-hederin was found ineffective for the second phase, either. Despite hederasaponin-C and -E were found effective in the second phase of inflammation, they were not found as effective as indomethacin and hederacolchiside-F. As a conclusion, hederasaponin-C, -E and -F, may exert their anti-inflammatory effects by blocking bradykinin or other inflammation mediators. The latter affect may occur via affecting prostaglandin pathways. Regarding the structure activity relationship, it is likely that sugars at [C.sub.3] position and Rha7-Glc1-6Glc moiety at [C.sub.28] position are essential for the acute anti-inflammatory effect.
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