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(DOWNLOAD) "Adenine-Based Calcium Signal Pathway Messengers: Synthesis and Agonistic Properties of Cyclic Adp-Ribose Analogs (Adenosine Diphosphate) (Report)" by Pure and Applied Chemistry * Book PDF Kindle ePub Free

Adenine-Based Calcium Signal Pathway Messengers: Synthesis and Agonistic Properties of Cyclic Adp-Ribose Analogs (Adenosine Diphosphate) (Report)

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eBook details

  • Title: Adenine-Based Calcium Signal Pathway Messengers: Synthesis and Agonistic Properties of Cyclic Adp-Ribose Analogs (Adenosine Diphosphate) (Report)
  • Author : Pure and Applied Chemistry
  • Release Date : January 01, 2008
  • Genre: Chemistry,Books,Science & Nature,
  • Pages : * pages
  • Size : 201 KB

Description

Abstract: A series of cyclic ADP-ribose (cADPR) analogs, in which modifications mainly focused on riboses, was synthesized in order to explore the molecular mechanism of calcium release regulated by cADPR. Biological activities investigated in intact T-lymphocytes showed that the structurally simplified analogs, N1-ethoxymethyl-substituted cyclic inosine diphosphoribose (cIDPRE), N1,N9-diethoxymethyl-substituted cyclic inosine diphosphoribose (cIDPDE), and N1-ethoxymethyl-substituted cyclic adenosine diphosphoribose (cADPRE) in which the northern ribose or both northern and southern riboses were replaced by ether linkages are membrane-permeant and induce calcium release from intracellular stores. This research has provided novel molecules to probe cADPR-mediated calcium signaling and enlarges our knowledge of the structure-activity relationships of cADPR analogs. Keywords: cADPR analogs; agonists; nucleotides; synthesis; signal messengers.


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